Ayabe T, Satchell D P, Wilson C L, Parks W C, Selsted M E, Ouellette A J
Department of Pathology, College of Medicine, University of California, Irvine, CA 92697, USA.
Nat Immunol. 2000 Aug;1(2):113-8. doi: 10.1038/77783.
Paneth cells in mouse small intestinal crypts secrete granules rich in microbicidal peptides when exposed to bacteria or bacterial antigens. The dose-dependent secretion occurs within minutes and alpha-defensins, or cryptdins, account for 70% of the released bactericidal peptide activity. Gram-negative bacteria, Gram-positive bacteria, lipopolysaccharide, lipoteichoic acid, lipid A and muramyl dipeptide elicit cryptdin secretion. Live fungi and protozoa, however, do not stimulate degranulation. Thus intestinal Paneth cells contribute to innate immunity by sensing bacteria and bacterial antigens, and discharge microbicidal peptides at effective concentrations accordingly.
小鼠小肠隐窝中的潘氏细胞在接触细菌或细菌抗原时会分泌富含杀菌肽的颗粒。这种剂量依赖性分泌在几分钟内发生，α-防御素（即隐窝素）占释放的杀菌肽活性的70%。革兰氏阴性菌、革兰氏阳性菌、脂多糖、脂磷壁酸、脂质A和胞壁酰二肽可引发隐窝素分泌。然而，活真菌和原生动物不会刺激脱颗粒。因此，肠道潘氏细胞通过感知细菌和细菌抗原，为先天免疫做出贡献，并相应地释放有效浓度的杀菌肽。
