Bromberg J
Rockefeller University and Memorial Sloan Kettering Cancer Center, 1230 York Avenue, New York, NY 10021, USA.
Breast Cancer Res. 2000;2(2):86-90. doi: 10.1186/bcr38. Epub 2000 Jan 28.
STAT transcription factors were discovered 10 years ago as mediators of interferon-induced gene expression. They now form an important group, comprising seven members, that are activated by virtually every cytokine and growth factor. Their critical role in development and normal cell signaling has been largely determined through the analysis of transgenic mice lacking individual STAT genes. In addition, cell culture work has further delineated their importance in cellular transformation, apoptosis, differentiation and growth control. This review discusses the specific phenotypes of STAT-deficient animals with a focus on STAT5 and STAT3, as these two STAT molecules are required for normal breast development and involution, respectively, and may play an important role in breast carcinogenesis.
信号转导和转录激活因子（STAT）转录因子于10年前作为干扰素诱导基因表达的介质被发现。它们现在构成了一个重要的家族，由七个成员组成，几乎可被每种细胞因子和生长因子激活。通过对缺乏单个STAT基因的转基因小鼠的分析，很大程度上确定了它们在发育和正常细胞信号传导中的关键作用。此外，细胞培养研究进一步阐明了它们在细胞转化、凋亡、分化和生长控制中的重要性。本综述讨论了STAT缺陷动物的特定表型，重点是STAT5和STAT3，因为这两种STAT分子分别是正常乳腺发育和退化所必需的，并且可能在乳腺癌发生中起重要作用。
