Medical Faculty, Trakia University, 6000 Stara Zagora, Bulgaria.
Medical Faculty, Sofia University St. Kliment Ohridski, 1 Kozyak Str., 1407 Sofia, Bulgaria.
Int J Mol Sci. 2024 Jan 13;25(2):1009. doi: 10.3390/ijms25021009.
Cancer remains one of the leading causes of morbidity and mortality worldwide, necessitating continuous efforts to develop effective therapeutic strategies. Over the years, advancements in our understanding of the complex interplay between the immune system and cancer cells have led to the development of immunotherapies that revolutionize cancer treatment. Cytokines, as key regulators of the immune response, are involved in both the initiation and progression of cancer by affecting inflammation and manipulating multiple intracellular signaling pathways that regulate cell growth, proliferation, and migration. Cytokines, as key regulators of inflammation, have emerged as promising candidates for cancer therapy. This review article aims to provide an overview of the significance of cytokines in cancer development and therapy by highlighting the importance of targeting cytokine signaling pathways as a potential therapeutic approach.
癌症仍然是全球发病率和死亡率的主要原因之一,因此需要不断努力开发有效的治疗策略。多年来,我们对免疫系统和癌细胞之间复杂相互作用的理解的提高,导致了免疫疗法的发展,从而彻底改变了癌症的治疗方法。细胞因子作为免疫反应的关键调节剂,通过影响炎症和操纵调节细胞生长、增殖和迁移的多个细胞内信号通路,参与癌症的发生和发展。细胞因子作为炎症的关键调节剂,已成为癌症治疗的有前途的候选药物。本文旨在通过强调靶向细胞因子信号通路作为一种潜在的治疗方法的重要性,概述细胞因子在癌症发展和治疗中的重要性。