Chiarle R, Pagano M, Inghirami G
Department of Pathology, New York University School of Medicine, New York, USA.
Breast Cancer Res. 2001;3(2):91-4. doi: 10.1186/bcr277. Epub 2000 Dec 20.
p27 is an inhibitor of cyclin dependent kinase involved in the regulation of the cell cycle. In this commentary we discuss the current knowledge on p27 in breast cancer and its significance in predicting the outcome. p27 protein levels are high in most cases of breast carcinomas, are correlated with the levels of cyclin D1 and estrogen receptor, and could be a useful predictor of survival, because they are low in aggressive carcinomas. Immunodetection of p27 in breast tumors could be useful in the assessment of prognosis, especially in those cases in which the commonly used parameters are insufficient, and might ultimately influence the therapy of this disease.
p27是一种参与细胞周期调控的细胞周期蛋白依赖性激酶抑制剂。在本评论中，我们讨论了目前关于p27在乳腺癌中的知识及其在预测预后方面的意义。在大多数乳腺癌病例中，p27蛋白水平较高，与细胞周期蛋白D1和雌激素受体水平相关，并且可能是生存的有用预测指标，因为在侵袭性癌中其水平较低。乳腺肿瘤中p27的免疫检测在预后评估中可能有用，特别是在那些常用参数不足的病例中，并且最终可能会影响这种疾病的治疗。
