Shang X J, Huang Y F, Xiong C L, Xu J P, Yin L, Wan C C
Center of Reproductive Medicine, Tongji Medical University, Wuhan 430030, China.
Asian J Androl. 1999 Sep;1(3):127-9.
To study the relationship between Ureaplasma urealyticum (UU) infection and apoptosis of human spermatogenic cells.
Spermatogenic cells were observed under light microscope with Wright-Giemsa staining and by means of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate (dUTP)-biotin nick-end labeling (TUNEL) technique.
Apoptotic rate of UU-infected males (15.5% +/- 6.8%) was significantly higher than that of controls (5.2% +/- 2.3%).
Apoptosis of spermatogenic cells can be caused by UU infection, which provides further evidence for UU-induced male infertility.
研究解脲脲原体（UU）感染与人类生精细胞凋亡之间的关系。
采用瑞氏-吉姆萨染色在光学显微镜下观察生精细胞，并运用末端脱氧核苷酸转移酶介导的脱氧尿苷三磷酸（dUTP）-生物素缺口末端标记（TUNEL）技术进行检测。
UU感染男性的凋亡率（15.5%±6.8%）显著高于对照组（5.2%±2.3%）。
UU感染可导致生精细胞凋亡，这为UU所致男性不育提供了进一步的证据。
