用于药物发现的传统医学中使用的植物的价值。
The value of plants used in traditional medicine for drug discovery.
作者信息
Fabricant D S, Farnsworth N R
机构信息
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois-Chicago, Chicago, Illinois 60612, USA.
出版信息
Environ Health Perspect. 2001 Mar;109 Suppl 1(Suppl 1):69-75. doi: 10.1289/ehp.01109s169.
Abstract
In this review we describe and discuss several approaches to selecting higher plants as candidates for drug development with the greatest possibility of success. We emphasize the role of information derived from various systems of traditional medicine (ethnomedicine) and its utility for drug discovery purposes. We have identified 122 compounds of defined structure, obtained from only 94 species of plants, that are used globally as drugs and demonstrate that 80% of these have had an ethnomedical use identical or related to the current use of the active elements of the plant. We identify and discuss advantages and disadvantages of using plants as starting points for drug development, specifically those used in traditional medicine.
摘要
在本综述中，我们描述并讨论了几种选择高等植物作为最具成功可能性的药物开发候选对象的方法。我们强调了源自各种传统医学（民族医学）体系的信息的作用及其在药物发现目的方面的实用性。我们已经鉴定出122种结构明确的化合物，这些化合物仅从94种植物中获得，它们在全球范围内被用作药物，并证明其中80%具有与该植物活性成分当前用途相同或相关的民族医学用途。我们识别并讨论了将植物用作药物开发起点，特别是用作传统医学中使用的植物的优缺点。
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2
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3
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