Patwardhan Bhushan, Mashelkar Raghunath Anant
Interdisciplinary School of Health Sciences, University of Pune, Pune 411 007, India.
Drug Discov Today. 2009 Aug;14(15-16):804-11. doi: 10.1016/j.drudis.2009.05.009. Epub 2009 May 27.
Drug discovery strategies based on natural products and traditional medicines are re-emerging as attractive options. We suggest that drug discovery and development need not always be confined to new molecular entities. Rationally designed, carefully standardized, synergistic traditional herbal formulations and botanical drug products with robust scientific evidence can also be alternatives. A reverse pharmacology approach, inspired by traditional medicine and Ayurveda, can offer a smart strategy for new drug candidates to facilitate discovery process and also for the development of rational synergistic botanical formulations.
基于天然产物和传统药物的药物发现策略正再度成为颇具吸引力的选择。我们认为，药物发现与开发不必总是局限于新的分子实体。经过合理设计、精心标准化且具有充分科学证据的协同作用的传统草药配方和植物药产品也可以成为替代方案。受传统医学和阿育吠陀启发的反向药理学方法，可为新药候选物提供一种明智的策略，以促进发现过程，也有助于开发合理的协同植物配方。
