Trachtulec Z, Forejt J
Department of Mammalian Molecular Genetics, Institute of Molecular Genetics, Academy of Sciences of The Czech Republic, Prague.
Mamm Genome. 2001 Mar;12(3):227-31. doi: 10.1007/s003350010259.
Four mouse genes, programmed cell death 2 (Pdcd2 or Rp8), brain protein 44-like (Brp441), bystin-like (Bysl), and uncoordinated-93-like (Unc931) genes were mapped to Chromosome (Chr) 17. The orthologs of these and other mouse Chr 17 genes are localized on Chr III of Caenorhabditis elegans, thus defining a syntenic group conserved between vertebrates and nonvertebrates. In human, mouse, and snake, the PDCD2-, and TATA-binding protein (TBP)-encoding genes are adjacent tail-to-tail. The TBP- and PDCD2-encoding genes are linked also in Drosophila, and, together with proteasomal subunit C5 gene, they are syntenic in human, mouse, C. elegans, and Schizosaccharomyces pombe. The orthologs of tightly linked C. elegans genes, coding for BRP44L and PDCD2, map to about 2-Mb interval on human region 6q27 and on mouse Chr 17. Hitherto, 13 members of synteny conserved between C. elegans and vertebrates have been detected, of which six are located on Drosophila Chr X. Such a distribution of transcription units is nonrandom and could indicate a long-range cis-acting relationship among the genes within the conserved syntenic group.
四个小鼠基因，程序性细胞死亡2（Pdcd2或Rp8）、脑蛋白44样（Brp441）、bystin样（Bysl）和不协调93样（Unc931）基因被定位到17号染色体（Chr）上。这些基因以及其他小鼠17号染色体基因的直系同源基因定位于秀丽隐杆线虫的Ⅲ号染色体上，从而确定了脊椎动物和非脊椎动物之间保守的一个同线群。在人类、小鼠和蛇中，编码PDCD2和TATA结合蛋白（TBP）的基因尾对尾相邻。编码TBP和PDCD2的基因在果蝇中也相连，并且与蛋白酶体亚基C5基因一起，在人类、小鼠、秀丽隐杆线虫和粟酒裂殖酵母中是同线的。紧密连锁的秀丽隐杆线虫基因（编码BRP44L和PDCD2）的直系同源基因定位于人类6q27区域和小鼠17号染色体上约2-Mb的区间内。迄今为止，已检测到秀丽隐杆线虫和脊椎动物之间保守的13个同线成员，其中6个位于果蝇X染色体上。这种转录单位的分布是非随机的，可能表明保守同线群内基因之间存在远距离顺式作用关系。
