Xiao Bing, Fan Yanghua, Ye Minhua, Lv Shigang, Xu Bin, Chai Yi, Wu Miaojin, Zhu Xingen
Department of Neurosurgery, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Oncol Lett. 2018 Jun;15(6):9697-9702. doi: 10.3892/ol.2018.8601. Epub 2018 Apr 27.
Chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) is a steroid receptor that is broadly expressed in many tissues throughout embryonic development. Previous studies indicated that COUP-TFII is dysregulated in multiple types of cancer and serves crucial roles in cancer development. The mitochondrial pyruvate carrier 1 (MPC1) is involved in transporting pyruvate for entry into the citric acid cycle, an important event in cancer progression. However, the roles of COUP-TFII and MPC1 in glioma remain unknown. In the present study, it was demonstrated that MPC1 is downregulated in glioblastoma. Furthermore, the inhibition of COUP-TFII was able to increase MPC1 expression and inhibit the growth of glioblastoma cells and . The findings from the present study demonstrated that downregulation of COUP-TFII inhibits glioblastoma growth via targeting MPC1. Therefore, COUP-TFII is a potential therapeutic target for glioma.
鸡卵清蛋白上游启动子转录因子II（COUP-TFII）是一种类固醇受体，在胚胎发育过程中广泛表达于许多组织中。先前的研究表明，COUP-TFII在多种类型的癌症中表达失调，并在癌症发展中起关键作用。线粒体丙酮酸载体1（MPC1）参与转运丙酮酸以进入柠檬酸循环，这是癌症进展中的一个重要事件。然而，COUP-TFII和MPC1在胶质瘤中的作用仍不清楚。在本研究中，证明了MPC1在胶质母细胞瘤中表达下调。此外，抑制COUP-TFII能够增加MPC1的表达并抑制胶质母细胞瘤细胞的生长。本研究结果表明，COUP-TFII的下调通过靶向MPC1抑制胶质母细胞瘤的生长。因此，COUP-TFII是胶质瘤的一个潜在治疗靶点。
