细丝蛋白作为细胞力学与信号传导的整合者

Filamins as integrators of cell mechanics and signalling.

作者信息

Stossel T P, Condeelis J, Cooley L, Hartwig J H, Noegel A, Schleicher M, Shapiro S S

机构信息

Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

出版信息

Nat Rev Mol Cell Biol. 2001 Feb;2(2):138-45. doi: 10.1038/35052082.

DOI:10.1038/35052082

PMID:11252955

Abstract

Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.

摘要

细丝蛋白是一类大型肌动蛋白结合蛋白，可稳定精细的三维肌动蛋白网络，并将其与细胞膜相连。它们整合细胞的结构和信号功能，对胎儿发育和细胞运动至关重要。在此，我们描述这组蛋白的历史、结构和功能。