Black A, Allison D B, Shapses S A, Tilmont E M, Handy A M, Ingram D K, Roth G S, Lane M A
Molecular and Nutritional Physiology Unit, Gerontology Research Center, National Institute on Aging, Baltimore, Maryland 21224, USA.
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):B98-107. doi: 10.1093/gerona/56.3.b98.
Little is known regarding the effects of prolonged calorie restriction (CR) on skeletal health. We investigated long-term (11 years) and short-term (12 months) effects of moderate CR on bone mass and biochemical indices of bone metabolism in male rhesus monkeys across a range of ages. A lower bone mass in long-term CR monkeys was accounted for by adjusting for age and body weight differences. A further analysis indicated that lean mass, but not fat mass, was a strong predictor of bone mass in both CR and control monkeys. No effect of short-term CR on bone mass was observed in older monkeys (mean age, 19 years), although young monkeys (4 years) subjected to short-term CR exhibited slower gains in total body bone density and content than age-matched controls. Neither biochemical markers of bone turnover nor hormonal regulators of bone metabolism were affected by long-term CR. Although osteocalcin concentrations were significantly lower in young restricted males after 1 month on 30% CR in the short-term study, they were no longer different from control values by 6 months on 30% CR.
关于长期热量限制（CR）对骨骼健康的影响，我们知之甚少。我们研究了中度CR对不同年龄段雄性恒河猴骨量和骨代谢生化指标的长期（11年）和短期（12个月）影响。通过调整年龄和体重差异，长期CR猴子的骨量较低。进一步分析表明，在CR猴子和对照猴子中，瘦体重而非脂肪量是骨量的有力预测指标。在老年猴子（平均年龄19岁）中未观察到短期CR对骨量的影响，尽管接受短期CR的幼年猴子（4岁）全身骨密度和骨含量的增长比年龄匹配的对照猴子慢。长期CR既不影响骨转换的生化标志物，也不影响骨代谢的激素调节因子。在短期研究中，虽然在30%CR条件下1个月后，年轻受限雄性猴子的骨钙素浓度显著降低，但在30%CR条件下6个月时，它们与对照值不再有差异。
