Davis S R
Jean Hailes Foundation, 173 Carinish Rd, Clayton, Victoria 3168, Australia.
J Gend Specif Med. 2000 Jan-Feb;3(1):36-40.
An accumulating body of data indicates that many women experience a cluster of symptoms that are responsive to testosterone treatment and may be due to androgen deficiency. Characteristically, affected women complain of low libido, persistent fatigue, and diminished well-being and are found to have low circulating bioavailable testosterone. Whether the apparent therapeutic effects of testosterone are mediated via the androgen receptor or as a consequence of metabolism to estrogen is not known. Despite the lack of understanding of the mechanism(s) by which testosterone may enhance libido, the prescription of testosterone to women in a variety of formulations is becoming increasingly popular. This article provides an overview of the rationale for testosterone therapy in women, offers a broad definition of androgen deficiency in women based on the clinical experience of the author, and outlines the currently available options and potential risks of testosterone replacement in women.
越来越多的数据表明，许多女性会出现一系列对睾酮治疗有反应的症状，这些症状可能是由于雄激素缺乏所致。典型的情况是，受影响的女性抱怨性欲低下、持续疲劳和幸福感下降，并且发现其循环中生物可利用睾酮水平较低。睾酮明显的治疗效果是通过雄激素受体介导，还是作为代谢为雌激素的结果，目前尚不清楚。尽管对睾酮增强性欲的机制缺乏了解，但以各种剂型给女性开睾酮处方正变得越来越普遍。本文概述了女性睾酮治疗的基本原理，根据作者的临床经验对女性雄激素缺乏给出了宽泛的定义，并概述了目前女性睾酮替代的可用选择和潜在风险。
