Prieto G, McCall J W, Venco L, Genchi M, Simon F, Genchi C
Laboratorio de Parasitología, Facultad de Farmacia, Salamanca, Spain.
Vet Res. 2001 Jan-Feb;32(1):93-6. doi: 10.1051/vetres:2001114.
Somatic antigens from third stage larvae of Dirofilaria immitis (SL3) were used to detect IgG response against heartworm infection in 8 experimentally infected cats. A moderate specific anti-SL3 IgG response was found one month post-infection. Afterwards, antibodies decreased reaching a basal level 4 months post-infection and remained at this level until the end of the study. 6 months post-infection. Western blot analysis showed specific recognition of polypeptides of 79, 73, 60, 52, 40 and 39 kDa by sera from infected cats 1 month post-infection, but not by sera taken prior to the infection. The low antigenicity of the SL3 antigen in the cat should allow the parasite to escape the host's immune response.
犬恶丝虫第三期幼虫的体细胞抗原（SL3）用于检测8只实验感染猫针对心丝虫感染的IgG反应。感染后1个月发现了适度的特异性抗SL3 IgG反应。之后，抗体水平下降，在感染后4个月降至基础水平，并在该水平维持至研究结束。感染后6个月，蛋白质印迹分析显示，感染后1个月的受感染猫血清可特异性识别79、73、60、52、40和39 kDa的多肽，但感染前采集的血清则不能。SL3抗原在猫体内的低抗原性应使寄生虫能够逃避宿主的免疫反应。
