Khananaev L I, Fitsych S A
Biull Eksp Biol Med. 1975 Mar;79(3):83-4.
Tests were conducted on albino rats with experimental Guerin carcinoma. A method of the blood vessel injection and preparation of lucid and stained (with hematoxylin-eosine) sections, and determination of the density of the capillary network were used; intramuscular adrenaline injections proved to produce an inhibitory effect on the growth of Guerin carcinoma, this bein accompanied by its intensified microvascularization. Combined administration of cyclophosphan and adrenaline produced a marked antitumour effect on accout of an antiblastic actionof cyclophosphan enhanced by adrenaline. The detected direct relationship between the vascular system of Guerin carcinoma, the thickness of the capillary network and the effect of the theraputic action of cyclophospahan and adrenaline pointed to the role played by the blood supply of Guerin carcinoma in the antiblastic action of cyclophosphan in case of combined administration with adrenaline.
对患有实验性格林氏癌的白化大鼠进行了测试。采用了血管注射法、制备清晰且经苏木精 - 伊红染色的切片以及测定毛细血管网络密度的方法；事实证明，肌肉注射肾上腺素对格林氏癌的生长产生抑制作用，同时伴随着其微血管化增强。环磷酰胺和肾上腺素联合给药对格林氏癌产生了显著的抗肿瘤作用，这是由于肾上腺素增强了环磷酰胺的抗增殖作用。检测到的格林氏癌血管系统、毛细血管网络厚度与环磷酰胺和肾上腺素治疗作用效果之间的直接关系表明，在与肾上腺素联合给药的情况下，格林氏癌的血液供应在环磷酰胺的抗增殖作用中发挥了作用。
