[Changes in the concentration of free radicals in the organs of rats during experimental chemotherapy of Guérin tumor].

Kinetic description of the changes of free radical concentration in Geren tumour tissue and in the tissues of liver, lungs, brain at chemotherapeutic application of licopine, selenium and cyclophosphane was obtained by ESR method. Licopine application decreases free radical concentration in the tumour (after the stage of a short-time rise). Similar effects during some periods of the action of carotinoids and of a valuable inhibitor of oxidation--selenium, as well as the citostatics of cyclophosphane allow to suggest that the application of the drug of vitamine A group is expedient in tumour therapy.