Frankfurt O S
Vopr Onkol. 1975;21(10):63-7.
Cells of Ehrlich ascites tumor survived after cyclophosphamide injection showed no multiplication during 48 hours. As a result, vinblastine injection simultaneously with cyclophosphamide or following 24 hours produced no additional death of cells. The administration of cyclophosphamide 6 hours after vinblastine resulted in the death of cells 30 times as much as in the injection of both substances simultaneously. Synergism was due to the disappearance of cells in phase G from the population, which are resistant to cyclophosphamide. Tween 80 enhanced an antitumor effect of cyclophosphamide without increasing the toxicity.
注射环磷酰胺后存活的艾氏腹水瘤细胞在48小时内未增殖。因此，与环磷酰胺同时注射或在24小时后注射长春碱不会导致细胞额外死亡。在长春碱注射6小时后给予环磷酰胺导致的细胞死亡量是同时注射两种物质时的30倍。协同作用是由于群体中对环磷酰胺有抗性的G期细胞消失所致。吐温80增强了环磷酰胺的抗肿瘤作用而不增加其毒性。
