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A study of the factors affecting the aluminum oxide-trihydroxyindole procedure for the analysis of catecholamines.一项关于影响用于儿茶酚胺分析的氧化铝 - 三羟基吲哚法的因素的研究。
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2
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Am J Physiol. 1960 Oct;199:649-52. doi: 10.1152/ajplegacy.1960.199.4.649.
3
The extraneuronal uptake and localization of noradrenaline in the cat spleen and the effect on this of some drugs, of cold and of denervation.去甲肾上腺素在猫脾脏中的神经元外摄取与定位以及某些药物、寒冷和去神经支配对此的影响。
J Physiol. 1970 Mar;206(3):563-90. doi: 10.1113/jphysiol.1970.sp009031.
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5
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Br J Pharmacol. 1971 Sep;43(1):180-9. doi: 10.1111/j.1476-5381.1971.tb07167.x.
6
Uptake kinetics and ion requirements for extraneuronal uptake of noradrenaline by arterial smooth muscle and collagen.动脉平滑肌和胶原蛋白对去甲肾上腺素的神经元外摄取的摄取动力学及离子需求
Br J Pharmacol. 1973 Mar;47(3):556-67. doi: 10.1111/j.1476-5381.1973.tb08186.x.
7
Factors affecting the extraneuronal inactivation of noradrenaline in cardiac and smooth muscle.影响心脏和平滑肌中去甲肾上腺素细胞外失活的因素。
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去甲肾上腺素被人脐动脉摄取的动力学及一些特征

Kinetics and some characteristics of uptake of noradrenaline by the human umbilical artery.

作者信息

Gulati O D, Sivaramakrishna N

出版信息

Br J Pharmacol. 1975 Jan;53(1):152-4. doi: 10.1111/j.1476-5381.1975.tb07344.x.

DOI:10.1111/j.1476-5381.1975.tb07344.x
PMID:1125488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1666274/
Abstract

The uptake of exogenously added noradrenaline (NA) (0.5-2.5 mug/ml) by the human umbilical artery was linear with time up to 10 minutes. The uptake was saturable and could be described by the Michaelis-Menten equation. The uptake was cocaine-resistant, normetanephrine-sensitive, was considerably inhibited in the cold and was partially inhibited by Na+- deficiency. Of NA accumulated in the artery 31% could be washed out by NA-free medium. It is concluded that the mechanism of uptake of NA by the human umbilical artery is similar to the uptake2 mechanism.

摘要

人脐动脉对外源性添加的去甲肾上腺素（NA）（0.5 - 2.5微克/毫升）的摄取在长达10分钟的时间内与时间呈线性关系。摄取是可饱和的，可用米氏方程描述。摄取对可卡因有抗性，对去甲变肾上腺素敏感，在低温下显著受抑制，且部分受钠缺乏抑制。动脉中积累的NA有31%可被无NA培养基洗脱。结论是人脐动脉摄取NA的机制类似于摄取2机制。