Holmes W F, Macfarlane J T, Macfarlane R M, Hubbard R
University of Nottingham.
Br J Gen Pract. 2001 Mar;51(464):177-81.
Most patients who consult with acute lower respiratory symptoms receive antibiotics, usually without evidence of significant infection. The physical signs at presentation of acute lower respiratory tract illness and the rate at which symptoms resolve and normal activities recover is not well documented.
To examine in patients with lower respiratory tract infection (LRTi), their physical signs at presentation, their relationship to antibiotic prescribing, and symptom resolution and resumption of normal activities.
Analysis of data collected prospectively during presentation of acute LRTi in primary care and from patient symptom diary cards.
Forty GPs who were members of an informal Community Respiratory Infection Interest Group recruited 391 patients to the study.
Information was collected on pulse, oral temperature, respiratory rate, abnormalities on auscultation, and details of any antibiotic prescription. Patients completed symptom diary cards for the following 10 days.
Of the 391 patients who consulted 71% received antibiotics. A minority had abnormal physical signs: 17% had a pulse greater than 90 bpm, 15% a respiratory rate greater than 20 breaths per minute, 4% had a temperature greater than 38 degrees C, and 25% had an abnormality on auscultation. Antibiotic prescribing was more common in the presence of abnormal chest signs (odds ratio = 8.71, 95% confidence interval = 3.69-20.61) or discoloured sputum (OR = 2.67, 95% CI = 1.57-4.56). Ten days after consultation, 58% of patients were still coughing and 29% had not returned to normal activities.
Abnormal physical signs at presentation do not explain the high rates of antibiotic prescribing nor do they predict persisting cough and functional impairment at 10 days. Reconsultation for the same symptoms within a month is common and is strongly related to persisting cough, but not abnormalities at presentation.
大多数因急性下呼吸道症状就诊的患者会接受抗生素治疗,通常并无明显感染的证据。急性下呼吸道疾病就诊时的体征以及症状缓解和恢复正常活动的速度尚无充分记录。
研究下呼吸道感染(LRTi)患者就诊时的体征、体征与抗生素处方的关系以及症状缓解和恢复正常活动的情况。
对基层医疗中急性LRTi就诊时前瞻性收集的数据以及患者症状日记卡进行分析。
40名作为非正式社区呼吸道感染兴趣小组成员的全科医生招募了391名患者参与本研究。
收集了脉搏、口腔温度、呼吸频率、听诊异常情况以及任何抗生素处方的详细信息。患者在接下来的10天内填写症状日记卡。
在391名就诊患者中,71%接受了抗生素治疗。少数患者有异常体征:17%的患者脉搏大于90次/分钟,15%的患者呼吸频率大于20次/分钟,4%的患者体温高于38摄氏度,25%的患者听诊有异常。胸部体征异常(优势比=8.71,95%置信区间=3.69-20.61)或痰液变色(优势比=2.67,95%置信区间=1.57-4.56)时,抗生素处方更为常见。就诊10天后,58%的患者仍在咳嗽,29%的患者尚未恢复正常活动。
就诊时的异常体征既不能解释抗生素的高处方率,也不能预测10天时持续咳嗽和功能障碍的情况。一个月内因相同症状再次就诊很常见,且与持续咳嗽密切相关,但与就诊时的异常情况无关。