Orton C I, Segal A W, Bloom S R, Clarke J
Br Med J. 1975 Apr 26;2(5964):170-2. doi: 10.1136/bmj.2.5964.170.
Hyperglucagonaemia and hypergastrinaemia were observed in some severely burnt patients during their illness. Hyperglucagonaemia seemed to be related to the severity of illness rather than to the burn itself, and the close correlation of glucagon concentrations with glucose and urea and its inverse correlation with bicarbonate concentrations suggest that glucagon might contribute to the hypercatabolic state. One patient developed high levels of gastrin and massive bleeding from a stress ulcer of the duodenum. Possibly gastrin hypersecretion may have a role in the pathogenesis of Curling's ulcer.
在一些严重烧伤患者患病期间观察到高胰高血糖素血症和高胃泌素血症。高胰高血糖素血症似乎与疾病严重程度有关，而非烧伤本身，胰高血糖素浓度与葡萄糖、尿素密切相关，与碳酸氢盐浓度呈负相关，这表明胰高血糖素可能促成了高分解代谢状态。一名患者出现高胃泌素水平，并发生十二指肠应激性溃疡大出血。胃泌素分泌过多可能在Curling溃疡的发病机制中起作用。
