Chubb J R, Insall R H
School of Biosciences, Birmingham University, B15 2TT, Birmingham, UK.
Biochim Biophys Acta. 2001 Mar 15;1525(3):262-71. doi: 10.1016/s0304-4165(01)00111-8.
Signalling pathways based on the small GTPase Ras regulate a multitude of cellular events in eukaryotic cells. Dictyostelium expresses a large and varied family of Ras proteins. It also uses a range of known Ras regulators, in particular RasGEFs, and effectors. The genetic tractability of Dictyostelium, together with the wide range of Ras proteins and regulators, make it an ideal model for the genetic dissection of Ras pathways. This review highlights the recent advances in our understanding of Ras function in Dictyostelium, and considers the implications of these findings for our understanding of eukaryotic signal transduction.
基于小GTP酶Ras的信号通路调控真核细胞中的众多细胞事件。盘基网柄菌表达一个庞大且多样的Ras蛋白家族。它还使用一系列已知的Ras调节因子，特别是RasGEF和效应器。盘基网柄菌的遗传易处理性，以及广泛的Ras蛋白和调节因子，使其成为Ras信号通路遗传剖析的理想模型。本综述重点介绍了我们对盘基网柄菌中Ras功能理解的最新进展，并考虑了这些发现对我们理解真核信号转导的意义。
