Moscat J, Diaz-Meco M T
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Universidad Autónoma, Canto Blanco, Spain.
EMBO Rep. 2000 Nov;1(5):399-403. doi: 10.1093/embo-reports/kvd098.
Since its discovery more than 10 years ago, the atypical PKC (aPKC) subfamily has attracted great interest. A number of reports have shown that the kinases of this subfamily play critical roles in signaling pathways that control cell growth, differentiation and survival. Recently, several investigators have identified a number of aPKC-interacting proteins whose characterization is helping to unravel the mechanisms of action and functions of these kinases. These interactors include p62, Par-6, MEK5 and Par-4. The details of how these adapters serve to link the aPKCs to different receptor signaling pathways and substrates in response to specific stimuli are crucial not only for developing an understanding of the roles and functions of the aPKCs themselves, but also for more generally establishing a view of how specificity in signal transduction is achieved.
自10多年前被发现以来，非典型蛋白激酶C（aPKC）亚家族就引起了极大关注。许多报告表明，该亚家族的激酶在控制细胞生长、分化和存活的信号通路中发挥着关键作用。最近，一些研究人员鉴定出了许多与aPKC相互作用的蛋白，对这些蛋白的特性描述有助于揭示这些激酶的作用机制和功能。这些相互作用蛋白包括p62、Par-6、MEK5和Par-4。这些衔接蛋白如何在特定刺激下将aPKC与不同的受体信号通路和底物联系起来的细节，不仅对于理解aPKC自身的作用和功能至关重要，而且对于更全面地了解信号转导特异性是如何实现的也至关重要。
