JAB1/CSN5与COP9信号体。情况复杂。
JAB1/CSN5 and the COP9 signalosome. A complex situation.
作者信息
Chamovitz D A, Segal D
机构信息
Department of Plant Sciences, Tel Aviv University, Israel.
出版信息
EMBO Rep. 2001 Feb;2(2):96-101. doi: 10.1093/embo-reports/kve028.
Abstract
The Jun activating binding protein (JAB1) specifically stabilizes complexes of c-Jun or JunD with AP-1 sites, increasing the specificity of target gene activation by AP-1 proteins. JAB1 is also known as COP9 signalosome subunit 5 (CSN5), which is a component of the COP9 signalosome regulatory complex (CSN). Over the past year, JAB1/CSN5 has been implicated in numerous signaling pathways including those that regulate light signaling in plants, larval development in Drosophila, and integrin signaling, cell cycle control, and steroid hormone signaling in a number of systems. However, the general role of the CSN complex, and the specific role of JAB1/CSN5, still remain obscure. This review attempts to integrate the available data to help explain the role of JAB1/CSN5 and the COP9 signalosome in regulating multiple pathways (in this review, both JAB1 and CSN5 terminologies are used interchangeably, depending on the source material).
摘要
Jun激活结合蛋白（JAB1）特异性地稳定c-Jun或JunD与AP-1位点的复合物，增强AP-1蛋白激活靶基因的特异性。JAB1也被称为COP9信号体亚基5（CSN5），它是COP9信号体调节复合物（CSN）的一个组成部分。在过去的一年里，JAB1/CSN5已涉及众多信号通路，包括调节植物光信号、果蝇幼虫发育以及多个系统中的整合素信号、细胞周期控制和类固醇激素信号等通路。然而，CSN复合物的总体作用以及JAB1/CSN5的具体作用仍不清楚。本综述试图整合现有数据，以帮助解释JAB1/CSN5和COP9信号体在调节多种通路中的作用（在本综述中，根据原始材料，JAB1和CSN5这两个术语可互换使用）。
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