Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Cell Mol Med. 2021 Mar;25(6):2750-2763. doi: 10.1111/jcmm.16334. Epub 2021 Feb 7.
c-Jun activation domain-binding protein-1 (Jab1) is aberrantly overexpressed in multiple cancers and plays an oncogenic role in cancer progression. We examined the association between Jab1 expression and prognosis in patients with cancer by conducting a meta-analysis. A comprehensive search strategy was performed using the PubMed, Web of Science, Ovid and EMBASE in July 2020. Eligible studies were enrolled according to definite criteria. Twenty-seven studies involving 2609 patients were enrolled in this meta-analysis. A significant association between high Jab1 expression and poor overall survival (pooled hazard ratio [HR] 2.344, 95% confidence interval [CI]: 2.037-2.696) was observed. Subgroup analyses of the type of cancer, sample size, follow-up period, Jab1 detection method and preoperative treatment did not alter the significance. On pooling data from Cox multivariate analyses, high Jab1 expression was found to be an independent prognostic indicator for overall survival. In addition, high Jab1 expression was found to be associated with advanced clinicopathological features such as clinical stage, lymphatic metastasis, histological grade and distant metastasis in cancers. Our meta-analysis is the first to demonstrate that high Jab1 expression may be a promising indicator of poor prognosis and has an independent prognostic value for overall survival in patients with cancer.
c-Jun 激活域结合蛋白-1（Jab1）在多种癌症中异常过表达，并且在癌症进展中发挥致癌作用。我们通过进行荟萃分析来研究 Jab1 表达与癌症患者预后之间的关系。我们于 2020 年 7 月使用 PubMed、Web of Science、Ovid 和 EMBASE 进行了全面的检索策略。根据明确的标准纳入了符合条件的研究。这项荟萃分析共纳入了 27 项研究，涉及 2609 名患者。结果表明，Jab1 高表达与总生存率降低显著相关（合并风险比[HR] 2.344，95%置信区间[CI]：2.037-2.696）。对癌症类型、样本量、随访时间、Jab1 检测方法和术前治疗的亚组分析并未改变这一意义。对 Cox 多因素分析的数据进行汇总分析后发现，Jab1 高表达是总生存率的独立预后指标。此外，在癌症中，Jab1 高表达与临床分期、淋巴转移、组织学分级和远处转移等晚期临床病理特征有关。本荟萃分析首次表明，Jab1 高表达可能是预后不良的一个有前途的指标，并且对癌症患者的总生存率具有独立的预后价值。
