Solomon J G
Postgrad Med. 1979 Sep;66(3):145-6, 148. doi: 10.1080/00325481.1979.11715252.
Epileptiform seizures occurred in a 34-year-old woman who was receiving amitriptyline and lithium carbonate therapy for treatment of endogenous depression. While receiving amitriptyline maintenance therapy, she was given lithium on two separate occasions, and despite serum levels of lithium in the therapeutic range, grand mal seizures developed. The seizures may represent a toxic reaction either to lithium or to combined drug therapy. Controlled studies are needed to evaluate both the efficacy and toxicity of combined drug therapy in affective disorders.
一名34岁女性在接受阿米替林和碳酸锂治疗内因性抑郁症时发生癫痫样发作。在接受阿米替林维持治疗期间，她曾两次接受锂剂治疗，尽管血清锂水平处于治疗范围内，但仍出现了癫痫大发作。这些发作可能代表对锂剂或联合药物治疗的毒性反应。需要进行对照研究以评估联合药物治疗在情感障碍中的疗效和毒性。
