Xu S, Zhu B T, Cai M X, Conney A H
Laboratory for Cancer Research, Department of Chemical Biology, College of Pharmacy, Rutgers, The State University of New Jersey, 164 Frelinghuysen Rd., Piscataway, NJ 08854-8020, USA.
J Pharmacol Exp Ther. 2001 Apr;297(1):50-6.
Treatment of ovariectomized rats with dietary clofibrate caused a manyfold increase in the liver microsomal esterification of estradiol with fatty acids. The stimulatory effect of clofibrate administration on fatty acid esterification of estradiol by liver microsomes was paralleled in vivo by enhanced estradiol-induced increases in the formation of lobules in the mammary gland and by increased incorporation of bromodeoxyuridine into these lobules. In contrast to the stimulatory effect of clofibrate administration on the action of estradiol in the mammary gland, clofibrate administration had no effect on the uterotropic action of estradiol. These results indicate that clofibrate administration has a selective stimulatory effect on the hormonal action of estradiol in the mammary gland but not in the uterus.
用饮食中的氯贝丁酯治疗去卵巢大鼠，会使肝脏微粒体中雌二醇与脂肪酸的酯化作用增加许多倍。氯贝丁酯给药对肝脏微粒体雌二醇脂肪酸酯化的刺激作用，在体内表现为雌二醇诱导的乳腺小叶形成增加，以及溴脱氧尿苷掺入这些小叶的增加。与氯贝丁酯给药对雌二醇在乳腺中作用的刺激效果相反，氯贝丁酯给药对雌二醇的子宫促生长作用没有影响。这些结果表明，氯贝丁酯给药对雌二醇在乳腺而非子宫中的激素作用具有选择性刺激作用。
