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发育中小脑细胞间的瞬时细胞质桥:细胞分化诱导的一种可能模式。

Transient cytoplasmic bridges among the cells of developing cerebellum: a possible mode of induction for cell differentiation.

作者信息

Das G D

出版信息

Cell Differ. 1975 Mar;3(6):371-7. doi: 10.1016/0045-6039(75)90005-6.

DOI:10.1016/0045-6039(75)90005-6
PMID:1125983
Abstract

In the developing cerebellum of neonate rats, membrane fusions and cytoplasmic bridges were observed between the pre-existing Purkinje cells and the migratory and differentiating granule cells. These ultrastructural specializations of the apposing membranes were seen to be transient in nature, and represented a developmental phenomenon. On the basis of literature available on this type of direct cell-to-cell interaction it is suggested that such transient cytoplasmic bridges may provide induction for differentiation from the pre-existing Purkinje cells to the undifferentiated cells.

摘要

在新生大鼠发育中的小脑中,在已有的浦肯野细胞与迁移和分化中的颗粒细胞之间观察到了膜融合和细胞质桥。这些相邻细胞膜的超微结构特化在本质上是短暂的,代表了一种发育现象。根据关于这种直接细胞间相互作用类型的现有文献,有人提出这种短暂的细胞质桥可能为从已有的浦肯野细胞到未分化细胞的分化提供诱导。

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引用本文的文献

1
Membrane-fusions and cytoplasmic bridges in the cells of the developing cerebellum.
Cell Tissue Res. 1977 Jan 24;176(4):475-92. doi: 10.1007/BF00231403.