婴儿皮肤黏液水肿病：它是一种独立的疾病实体还是黏液性苔藓（丘疹性黏液水肿）的儿童形式？

Cutaneous mucinosis of infancy: is it a real entity or the paediatric form of lichen myxoedematosus (papular mucinosis)?

作者信息

Podda M, Rongioletti F, Greiner D, Milbradt R, Rebora A, Kaufmann R, Wolter M

机构信息

Department of Dermatology, J.W.Goethe-University of Frankfurt, Germany.

出版信息

Br J Dermatol. 2001 Mar;144(3):590-3. doi: 10.1046/j.1365-2133.2001.04090.x.

DOI:10.1046/j.1365-2133.2001.04090.x

PMID:11260021

Abstract

We describe a girl presenting with a childhood dermal mucinosis in which we had the unique opportunity to find all the transitional histological features of lichen myxoedematosus (papular mucinosis), from its early focal mucin deposition in the reticular dermis to its late findings of interstitial mucin deposition, dermal fibrosis and fibroblast proliferation. Her father reported having had similar lesions when he was a child, which completely disappeared during adolescence. This case, and a re-evaluation of the literature, suggests that cases of cutaneous mucinosis of infancy that are not hamartomatous conditions such as mucinous naevi are in fact the infantile presentation of lichen myxoedematosus (papular mucinosis) and, in addition to other cases in the literature, suggests a genetic and familial factor in lichen myxoedematosus (papular mucinosis).

摘要

我们描述了一名患有儿童期皮肤黏蛋白沉积症的女孩，在此病例中，我们有独特的机会观察到黏液性苔藓（丘疹性黏蛋白沉积症）所有过渡性组织学特征，从其早期在网状真皮中的局灶性黏蛋白沉积，到晚期的间质黏蛋白沉积、真皮纤维化和成纤维细胞增殖。她的父亲报告说自己小时候也有类似的皮损，青春期时完全消失了。该病例以及对文献的重新评估表明，婴儿期非错构瘤性皮肤黏蛋白沉积症（如黏液性痣）实际上是黏液性苔藓（丘疹性黏蛋白沉积症）的婴儿期表现，并且除文献中的其他病例外，提示黏液性苔藓（丘疹性黏蛋白沉积症）存在遗传和家族因素。