Schultz A B, Brat D J, Oyesiku N M, Hunter S B
Department of Pathology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA.
Arch Pathol Lab Med. 2001 Apr;125(4):527-30. doi: 10.5858/2001-125-0527-IPIAPW.
Considered a neoplasm of pituicytes, pituicytoma is a rare and distinct type of glioma that arises in the suprasellar space and within the sella turcica. Only 12 previously reported cases of pituicytoma are documented in the literature. We report an intrasellar pituicytoma in a 66-year-old man presenting with symptoms and radiologic appearance indistinguishable from a nonfunctional pituitary adenoma. The patient also had a medical history significant for parathyroid adenomas and follicular carcinoma of the thyroid. The intrasellar tumor had morphologic features of a pituicytoma, with interlacing fascicles and a storiform pattern much like a benign fibrous histiocytoma. Immunoreactivity for S100 was strong, but the tumor lacked intercellular collagen type IV. The differential diagnosis of a low-grade spindle cell lesion of the sellar space is discussed, and the literature is reviewed. A summary of the clinical and pathologic features of this case, as well as the 12 previously reported cases, is presented.
垂体细胞瘤被认为是一种垂体细胞的肿瘤，是一种罕见且独特的胶质瘤类型，发生于鞍上区和蝶鞍内。文献中仅记载了12例先前报道的垂体细胞瘤病例。我们报告了1例66岁男性的鞍内垂体细胞瘤，其症状和影像学表现与无功能垂体腺瘤难以区分。该患者还有甲状旁腺腺瘤和甲状腺滤泡癌的病史。鞍内肿瘤具有垂体细胞瘤的形态学特征，有交织的束状结构和车辐状排列，很像良性纤维组织细胞瘤。S100免疫反应性强，但肿瘤缺乏细胞间IV型胶原。讨论了鞍区低度梭形细胞病变的鉴别诊断，并对文献进行了综述。本文介绍了该病例以及先前报道的12例病例的临床和病理特征总结。
