Wall T L, Shea S H, Chan K K, Carr L G
Department of Psychiatry, University of California, San Diego, and Psychology Service, Veterans Affairs San Diego Healthcare System, USA.
J Abnorm Psychol. 2001 Feb;110(1):173-8. doi: 10.1037//0021-843x.110.1.173.
Studies of Asian adults have found that alcohol use and alcohol dependence are related to variation in the aldehyde dehydrogenase (ALDH2) gene. To investigate the association of ALDH2 with the development of drug involvement, the authors analyzed retrospective information about the onset and regular use of alcohol and other substances as reported by 180 Asian American college students. Possession of an ALDH22 allele was not related to initiation of alcohol use or having ever been intoxicated, but individuals with ALDH22 alleles were less likely to be regular drinkers, were less likely to have engaged in a binge-drinking episode, reported a lower number of maximum drinks consumed in a 24-hr period, and were less likely to have used tobacco regularly than those without this genetic variant. These findings suggest that ALDH2 is associated with the development of not only alcohol-related behavior but other substance use behavior as well.
对亚洲成年人的研究发现，饮酒及酒精依赖与乙醛脱氢酶（ALDH2）基因的变异有关。为了研究ALDH2与药物使用发展之间的关联，作者分析了180名亚裔美国大学生报告的关于酒精及其他物质开始使用和规律使用的回顾性信息。携带ALDH22等位基因与开始饮酒或曾有过醉酒经历无关，但与没有这种基因变异的人相比，携带ALDH22等位基因的个体成为规律饮酒者的可能性较小，发生暴饮事件的可能性较小，报告的24小时内最大饮酒量较低，且经常使用烟草的可能性较小。这些发现表明，ALDH2不仅与酒精相关行为的发展有关，也与其他物质使用行为有关。
