Taylor C T, Brooks N C, Kelley K W
Department of Pharmacy Practice, School of Pharmacy, Auburn University, AL, USA.
Ann Pharmacother. 2001 Mar;35(3):365-8. doi: 10.1345/aph.10230.
To evaluate safety and efficacy of corticotropin for acute gout.
Clinical literature was accessed through MEDLINE (1966-August 2000). Key search terms included gout, ACTH, adrenocorticotropic hormone, and corticotropin.
Joint pain and local signs of inflammation characterize gout. Acutely, colchicine and nonsteroidal antiinflammatory drugs (NSAIDs) are first-line therapy. Adverse effects or concomitant diseases limit therapy and necessitate alternative options. An evaluation of studies involving corticotropin was conducted.
Corticotropin alone or in combination with colchicine was more rapidly effective and associated with fewer adverse effects than indomethacin. This regimen may be considered an alternative, especially for patients with medical problems in which other regimens are contraindicated.
评估促肾上腺皮质激素治疗急性痛风的安全性和有效性。
通过MEDLINE（1966年至2000年8月）检索临床文献。关键检索词包括痛风、促肾上腺皮质激素、促肾上腺皮质激素释放激素和促肾上腺皮质激素。
关节疼痛和局部炎症体征是痛风的特征。急性发作时，秋水仙碱和非甾体抗炎药（NSAIDs）是一线治疗药物。不良反应或合并疾病限制了治疗，因此需要其他选择。对涉及促肾上腺皮质激素的研究进行了评估。
促肾上腺皮质激素单独使用或与秋水仙碱联合使用比吲哚美辛起效更快，不良反应更少。该治疗方案可作为一种替代方案，特别是对于有其他治疗方案禁忌的内科疾病患者。
