Salacinski H J, Goldner S, Giudiceandrea A, Hamilton G, Seifalian A M, Edwards A, Carson R J
University Department of Surgery, Royal Free and University College Medical School, University College London and The Royal Free Hospital, UK.
J Biomater Appl. 2001 Jan;15(3):241-78. doi: 10.1106/NA5T-J57A-JTDD-FD04.
The development of intimal hyperplasia (IH) near the anastomosis of a vascular graft to artery is directly related to changes in the wall shear rate distribution. Mismatch in compliance and diameter at the end-to-end anastomosis of a compliant artery and rigid graft cause shear rate disturbances that may induce intimal hyperplasia and ultimately graft failure. The principal strategy being developed to prevent IH is based on the design and fabrication of compliant synthetic or innovative tissue-engineered grafts with viscoelastic properties that mirror those of the human artery. The goal of this review is to discuss how mechanical properties including compliance mismatch, diameter mismatch, Young's modulus and impedance phase angle affect graft failure due to intimal hyperplasia.
血管移植物与动脉吻合口附近内膜增生（IH）的发展与壁面剪切率分布的变化直接相关。顺应性动脉与刚性移植物在端端吻合处的顺应性和直径不匹配会导致剪切率紊乱，这可能会引发内膜增生并最终导致移植物失败。目前正在开发的预防内膜增生的主要策略是基于设计和制造具有与人动脉相似粘弹性特性的顺应性合成或创新性组织工程移植物。这篇综述的目的是讨论包括顺应性不匹配、直径不匹配、杨氏模量和阻抗相位角在内的机械性能如何影响因内膜增生导致的移植物失败。
