Jeong YeJin, Yao Yuan, Yim Evelyn K F
Department of Chemical engineering, University of Waterloo, 200 University Ave W, Waterloo, ON N2L 3G1, Canada.
Biomater Sci. 2020 Aug 21;8(16):4383-4395. doi: 10.1039/d0bm00226g. Epub 2020 Jul 9.
Despite much effort, synthetic small diameter vascular grafts still face limited success due to vascular wall thickening known as intimal hyperplasia (IH). Compliance mismatch between graft and native vessels has been proposed to be one of a key mechanical factors of synthetic vascular grafts that could contribute to the formation of IH. While many methods have been developed to determine compliance both in vivo and in vitro, the effects of compliance mismatch still remain uncertain. This review aims to explain the biomechanical factors that are responsible for the formation and development of IH and their relationship with compliance mismatch. Furthermore, this review will address the current methods used to measure compliance both in vitro and in vivo. Lastly, current limitations in understanding the connection between the compliance of vascular grafts and the role it plays in the development and progression of IH will be discussed.
尽管付出了诸多努力，但合成小口径血管移植物仍因血管壁增厚（即内膜增生，IH）而成效有限。移植物与天然血管之间的顺应性不匹配被认为是合成血管移植物可能导致内膜增生形成的关键机械因素之一。虽然已经开发出许多体内和体外测定顺应性的方法，但顺应性不匹配的影响仍不确定。本综述旨在解释导致内膜增生形成和发展的生物力学因素及其与顺应性不匹配的关系。此外，本综述将阐述目前用于体外和体内测量顺应性的方法。最后，将讨论目前在理解血管移植物顺应性与其在内膜增生发展和进程中所起作用之间联系方面的局限性。
