Szaniszló J, Ungváry G
József Fodor National Center for Public Health, Budapest, Hungary.
J Toxicol Environ Health A. 2001 Mar 9;62(5):297-306. doi: 10.1080/152873901300017995.
Polycyclic aromatic hydrocarbons exposure (PAHs: (benz[a]anthracene, benzo[a]pyrene, dibenz[a,h]anthracene, benzo[b]fluoranthene, benzo[k]fluoranthene, indeno[1,2,3-cd]-pyrene, fluoranthene, chrysene, pyrene) of policemen on street duty in downtown Budapest and workers repairing the road (asphalting) at a traffic junction and their excretion of PAH metabolites (1-hydroxypyrene, 3-hydroxybenz[a]anthracene, and 3-hydroxybenzo[a]pyrene) were determined. As controls, health-care workers were investigated. In addition PAH pollution of the air of a factory processing asphalt was also measured. The measurements were performed on air samples gained using personal samplers and from urine of end-shift samples using a high-performance liquid chromatography method. It was found that PAH pollution of the most crowded and busy center of Budapest was similar to that of several other cities in the world. PAH exposure of road builders was actually not higher than that of policemen; the slight difference resulted from diverging life-styles. PAH metabolite excretion of smoking health-care workers, road builders, or policemen significantly exceeded that of the nonsmokers. The PAH metabolite values of the three groups engaged in various activities did not show any difference. It was concluded that cancer-related risk due to PAH compounds in the case of policemen on street duty and road builders (asphalting) does not exceed significantly that of workers not exposed occupationally to PAHs in the ambient air, but that smoking is a decisive factor.
测定了布达佩斯市中心街头执勤警察和在交通枢纽修路（铺设沥青）工人的多环芳烃暴露情况（多环芳烃：苯并[a]蒽、苯并[a]芘、二苯并[a,h]蒽、苯并[b]荧蒽、苯并[k]荧蒽、茚并[1,2,3-cd]芘、荧蒽、 Chrysene、芘）及其多环芳烃代谢物（1-羟基芘、3-羟基苯并[a]蒽和3-羟基苯并[a]芘）的排泄情况。作为对照，对医护人员进行了调查。此外，还测量了一家加工沥青工厂的空气污染情况。测量是使用个人采样器采集的空气样本以及使用高效液相色谱法对轮班结束时的尿液样本进行的。结果发现，布达佩斯最拥挤繁忙的市中心的多环芳烃污染与世界上其他几个城市相似。道路建设工人的多环芳烃暴露实际上并不高于警察；细微差异是由不同的生活方式导致的。吸烟的医护人员、道路建设工人或警察的多环芳烃代谢物排泄量明显超过不吸烟者。从事各种活动的三组人员的多环芳烃代谢物值没有显示出任何差异。得出的结论是，街头执勤警察和道路建设工人（铺设沥青）因多环芳烃化合物导致的癌症相关风险并不显著超过未在环境空气中职业性接触多环芳烃的工人，但吸烟是一个决定性因素。
