Strauer B E
Dtsch Med Wochenschr. 1975 Apr 4;100(14):760-3. doi: 10.1055/s-0028-1106289.
The effect of tilidine (Valoron, 1.5 mg/kg) on left-ventricular function was measured in ten patients undergoing diagnostic cardiac catheterization. In the course of thirty minutes after administration there was a small fall in systemic arterial pressure, decrease in cardiac output, cardiac index and stroke volume, as well as a change in the isovolumetric inotropic state. Haemodynamic and inotropic changes were small in amount, varying between 3.4 and 14.5% of basal values. This study indicates that tilidine, while having a powerful analgesic effect, has only a mild contractility-inhibiting action. Tilidine is thus a useful alternative as an analgesic in cardiac pain.
在十名接受诊断性心导管插入术的患者中，测量了替利定（瓦洛隆，1.5毫克/千克）对左心室功能的影响。给药后30分钟内，体循环动脉压略有下降，心输出量、心脏指数和每搏输出量减少，等容性变力状态也发生了变化。血流动力学和变力变化幅度较小，在基础值的3.4%至14.5%之间。这项研究表明，替利定虽然具有强大的镇痛作用，但只有轻微的收缩力抑制作用。因此，替利定是治疗心脏疼痛的一种有用的替代镇痛药。
