Lankisch P G, Fuchs K, Schmidt H, Peiper H J, Creutzfeldt W
Dtsch Med Wochenschr. 1975 May 9;100(19):1048-50, 1059-60. doi: 10.1055/s-0028-1106333.
Studies were undertaken in 40 patients with chronic pancreatitis six months to seven and a half years (mean 25 months) after operation, results being compared with pre-operative findings. Measurements included: exercise capacity, absence of pain, body weight, endocrine (36) and exocrine (25) pancreatic function. Almost all patients returned to full or only slightly impaired activity, were free of pain or had less pain and weight increase. Exocrine pancreatic function (secretin-pancreozymin test and faecal fat) was noted in 11 of 25 patients. In another 11 pre-operative progression was arrested. But endocrine function improved in only three of 36 and worsened in 13 (manifestation of subclinical diabetes in eight, worse glucose tolerance in five). The results justify a more active surgical approach in the treatment of chronic pancreatitis in order to save the patients from an often long and painful "burning out" of the disease on purely conservative treatment. Furthermore, exocrine pancreatic function, at least, is maintained or improved.
对40例慢性胰腺炎患者在术后6个月至7年半（平均25个月）进行了研究，并将结果与术前检查结果进行比较。测量指标包括：运动能力、无疼痛情况、体重、内分泌（36例）和外分泌（25例）胰腺功能。几乎所有患者恢复了全部活动或仅活动稍有受限，无痛或疼痛减轻且体重增加。25例患者中有11例进行了外分泌胰腺功能检查（促胰液素-胰酶泌素试验和粪便脂肪检查）。另有11例术前病情进展得到控制。但36例患者中只有3例内分泌功能改善，13例恶化（8例出现亚临床糖尿病表现，5例糖耐量变差）。这些结果证明在慢性胰腺炎治疗中采取更积极的手术方法是合理的，以便使患者避免在单纯保守治疗下疾病常常出现的漫长而痛苦的“消耗殆尽”过程。此外，至少外分泌胰腺功能得以维持或改善。
