Lankisch P G, Ehrhardt-Schmelzer S, Koop H, Caspary W F
Dtsch Med Wochenschr. 1980 Oct 10;105(41):1418-23. doi: 10.1055/s-2008-1070884.
The NBT-PABA test, an oral pancreatic function test, was performed in 67 patients with proven chronic pancreatitis (secretin pancreozymin test or intraoperatively) and was pathological in 60 (89.6%). Prolongation of urinary collection period from 6 to 9 hours did not improve the diagnostic value. In comparison with the NBT-PABA test the sensitivity of trypsin and chymotrypsin determination in stool was 40.6% and 62.2%, respectively. In severe exocrine pancreatic insufficiency when pathological fecal fat excretion was demonstrable (steathorrhea) the accuracy of fecal enzyme determination was clearly higher (59.1% and 91.8%, respectively). Thus the NBT-PABA test is an alternative diagnostic tool for exocrine pancreatic insufficiency when the secretin-pancreozymin test, and fecal enzyme and fecal fat determination are too complicated. However, as intact absorption of NBT-PABA is possible, the test only provides a qualitative and limited quantitative evaluation of pancreatic function.
对67例经证实的慢性胰腺炎患者（通过促胰液素-胰酶泌素试验或术中检查确诊）进行了口服胰腺功能试验——对氨基苯甲酸试验（NBT-PABA试验），其中60例（89.6%）结果呈病理性。将尿液收集时间从6小时延长至9小时并未提高诊断价值。与NBT-PABA试验相比，粪便中胰蛋白酶和糜蛋白酶测定的敏感性分别为40.6%和62.2%。在严重外分泌性胰腺功能不全且粪便脂肪排泄呈病理性（脂肪泻）时，粪便酶测定的准确性明显更高（分别为59.1%和91.8%）。因此，当促胰液素-胰酶泌素试验以及粪便酶和粪便脂肪测定过于复杂时，NBT-PABA试验是诊断外分泌性胰腺功能不全的一种替代诊断工具。然而，由于对氨基苯甲酸可能被完整吸收，该试验仅能对胰腺功能进行定性和有限的定量评估。
