Wang C, Li L, Lu F
Second Hospital, Hunan Medical University, Changsha 410011.
Zhonghua Fu Chan Ke Za Zhi. 1999 Mar;34(3):140-2.
To study the changes and clinical significance of plasma endothelin (ET-1) and calcitonin gene-related peptide (CGRP) levels in patients with pregnancy induced hypertension (PIH).
Plasma ET-1 and CGRP were studied by immunoradiological method in 60 patients with pregnancy induced hypertension (PIH) and 23 normal pregnant women and 20 normal non-pregnant women.
The levels of plasma ET-1 in patients with PIH were significantly higher than those in healthy pregnancies (P < 0.01). There was a positive correlation between the plasma ET-1 level and degree of PIH; the higher the ET-1 level, the severer the PIH. The levels of plasma CGRP in patients with moderate and severe PIH decreased significantly than those in healthy pregnancy. There was a negative correlation between the plasma CGRP level and ET-1 level.
The results suggest that plasma ET-1 and CGRP concentration could be used as indicators for the severity of PIH. CGRP may be one of the antagonists of ET-1 in the pathogenesis of PIH.
研究妊娠高血压综合征（PIH）患者血浆内皮素（ET-1）和降钙素基因相关肽（CGRP）水平的变化及其临床意义。
采用免疫放射法对60例妊娠高血压综合征患者、23例正常孕妇及20例正常非孕妇女的血浆ET-1和CGRP进行检测。
PIH患者血浆ET-1水平显著高于正常妊娠者（P<0.01）。血浆ET-1水平与PIH病情程度呈正相关，ET-1水平越高，PIH病情越严重。中、重度PIH患者血浆CGRP水平显著低于正常妊娠者。血浆CGRP水平与ET-1水平呈负相关。
结果提示，血浆ET-1和CGRP浓度可作为PIH病情严重程度的指标。CGRP可能是PIH发病机制中ET-1的拮抗剂之一。
