Zhou Q, Sun M, Li X
Department of Internal Medicine, Xiangya Hospital, Hunan Medical University, Changsha.
Hunan Yi Ke Da Xue Xue Bao. 1997;22(4):335-7.
Plasma endothelin-1 (ET-1) and calcitonin gene related peptides (cGRP) were studied by immunoradiological method in 60 hemodialysis (HD) patients. The results showed that: (1) Plasma level of ET-1 and cGRP were increased in the HD patients. (2) Plasma level of ET-1 and cGRP varied in different times of HD. (3) A significantly positive relation between plasma ET-1 and blood pressure (BP) existed in the HD patients, while a significantly negative relation between plasma cGRP and BP existed in the HD patients. The results suggest that ET-1 and cGRP are major factors which lead to BP changes in HD patients.
采用免疫放射分析法对60例血液透析（HD）患者的血浆内皮素-1（ET-1）和降钙素基因相关肽（cGRP）进行了研究。结果显示：（1）HD患者血浆ET-1和cGRP水平升高。（2）HD不同时段血浆ET-1和cGRP水平有所变化。（3）HD患者血浆ET-1与血压（BP）呈显著正相关，而血浆cGRP与BP呈显著负相关。结果提示，ET-1和cGRP是导致HD患者血压变化的主要因素。
