[间质性肺疾病患者支气管肺泡灌洗液酶活性的研究]

[A study on enzymatic activities of bronchoalveolar lavage fluid in patients with interstitial lung diseases].

作者信息

Zheng J, Jia Y, Zhou K

机构信息

Affiliated ZhongShan Hospital of Shanghai Medical University, Shanghai 200032.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 1998 Feb;21(2):91-3.

PMID:11263392

Abstract

OBJECTIVE

To evaluate the relationship between enzymatic activities in bronchoalveolar lavage fluid(BALF) and interstitial lung diseases(ILDs).

METHOD

Cellular components and levels of superoxide dismutase (SOD), glutathione peroxidase(GSH-PX), angiotensin converting enzyme(ACE) and lactate dehydrogenase(LDH) in BALF in 30 cases of ILDs: including 18 patients with idiopathic pulmonary fibrosis (IPF) and 12 patients with sarcoidosis (Sarc) and 9 healthy controls were determined.

RESULT

(1) The levels of BALF-SOD, GSH-PX were significantly decreased(P < 0.01), and BALF-ACE, LDH were markedly increased (P < 0.05) in patients with IPF, and BALF-ACE were also increased in patients with Sarc(P < 0.05); (2) There were good correlation between ACE and percentage of lymphocyte (r1 = 0.6574, P < 0.05), and ratio of CD4+/CD8+ (r2 = 0.9544, P < 0.001) in BALF of Sarc group.

CONCLUSION

Determining enzymatic activities could be helpful to study pathogenesis and diagnosis of ILDs, BALF-ACE may be as a good marker of disease activity of Sarcoidosis.

摘要

目的

评估支气管肺泡灌洗液（BALF）中的酶活性与间质性肺疾病（ILDs）之间的关系。

方法

测定30例ILDs患者（包括18例特发性肺纤维化（IPF）患者和12例结节病（Sarc）患者）以及9名健康对照者BALF中的细胞成分和超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-PX）、血管紧张素转换酶（ACE）和乳酸脱氢酶（LDH）水平。

结果

（1）IPF患者BALF-SOD、GSH-PX水平显著降低（P<0.01），BALF-ACE、LDH水平显著升高（P<0.05），Sarc患者BALF-ACE水平也升高（P<0.05）；（2）Sarc组BALF中ACE与淋巴细胞百分比（r1 = 0.6574，P<0.05）及CD4+/CD8+比值（r2 = 0.9544，P<0.001）之间存在良好相关性。