1999年密苏里州与罗勒相关的环孢子虫病暴发。

Outbreak of cyclosporiasis associated with basil in Missouri in 1999.

作者信息

Lopez A S, Dodson D R, Arrowood M J, Orlandi P A, da Silva A J, Bier J W, Hanauer S D, Kuster R L, Oltman S, Baldwin M S, Won K Y, Nace E M, Eberhard M L, Herwaldt B L

机构信息

Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

出版信息

Clin Infect Dis. 2001 Apr 1;32(7):1010-7. doi: 10.1086/319597. Epub 2001 Mar 15.

DOI:10.1086/319597

PMID:11264028

Abstract

During the summer of 1999, an outbreak of cyclosporiasis occurred among attendees of 2 events held on 24 July in different counties in Missouri. We conducted retrospective cohort studies of the 2 clusters of cases, which comprised 62 case patients. The chicken pasta salad served at one event (relative risk [RR], 4.25; 95% confidence interval [CI], 1.80-10.01) and the tomato basil salad served at the other event (RR, 2.95; 95% CI, 1.72-5.07) were most strongly associated with illness. The most likely vehicle of infection was fresh basil, which was included in both salads and could have been grown either in Mexico or the United States. Leftover chicken pasta salad was found to be positive for Cyclospora DNA by means of polymerase chain reaction analysis, and 1 sporulated Cyclospora oocyst was found by use of microscopy. This is the second documented outbreak of cyclosporiasis in the United States linked to fresh basil and the first US outbreak for which Cyclospora has been detected in an epidemiologically implicated food item.

摘要

1999年夏天，密苏里州不同县于7月24日举办的两场活动的参与者中爆发了环孢子虫病疫情。我们对这两起病例群进行了回顾性队列研究，共涉及62例病例患者。在其中一场活动中供应的鸡肉意大利面沙拉（相对危险度[RR]，4.25；95%置信区间[CI]，1.80 - 10.01）以及在另一场活动中供应的番茄罗勒沙拉（RR，2.95；95% CI，1.72 - 5.07）与发病关联最为密切。最有可能的感染载体是新鲜罗勒，两种沙拉中都有它，其可能产自墨西哥或美国。通过聚合酶链反应分析发现，剩余的鸡肉意大利面沙拉中环孢子虫DNA呈阳性，并且通过显微镜检查发现了1个孢子化的环孢子虫卵囊。这是美国第二起有记录的与新鲜罗勒相关的环孢子虫病疫情，也是美国首次在具有流行病学关联的食品中检测到环孢子虫的疫情。