Soewignjo S, Gessner B D, Sutanto A, Steinhoff M, Prijanto M, Nelson C, Widjaya A, Arjoso S
Biomedical Research Unit, Mataram General Hospital, Mataram, Indonesia.
Clin Infect Dis. 2001 Apr 1;32(7):1039-43. doi: 10.1086/319605. Epub 2001 Mar 20.
Few data exist on childhood pneumococcal carriage prevalence, serotype distribution, and resistance patterns for Indonesia, the world's fourth most populous country. During August 1997, nasopharyngeal samples were collected from a population-based, island-wide sample of 484 healthy children (age, 0-25 months) from Lombok Island, Indonesia. Two hundred twenty-one pneumococcal isolates were identified, for a carriage prevalence of 48%; 66% of isolates were of serogroup or serotype 6, 23, 15, 33, or 12. All isolates were susceptible to penicillin and cefotaxime. Twelve percent of the isolates were nonsusceptible to sulfamethoxazole or chloramphenicol and 4% were nonsusceptible to both of these drugs. Nonsusceptible organisms were most frequently serogroup or serotype 6, 12, and 33. Lombok has a moderate pneumococcal carriage prevalence and a relatively low proportion of resistant isolates. At least 3 of the 5 most common serogroups and serotypes and 2 of the 3 most common nonsusceptible serogroups and serotypes are not included in the current 7-valent pneumococcal conjugate vaccine.
作为世界第四人口大国，印度尼西亚关于儿童肺炎球菌携带率、血清型分布及耐药模式的数据很少。1997年8月，从印度尼西亚龙目岛484名0至25个月健康儿童的全岛人群样本中采集了鼻咽样本。共鉴定出221株肺炎球菌分离株，携带率为48%；66%的分离株属于血清群或血清型6、23、15、33或12。所有分离株对青霉素和头孢噻肟敏感。12%的分离株对磺胺甲恶唑或氯霉素不敏感，4%的分离株对这两种药物均不敏感。不敏感菌株最常见的血清群或血清型为6、12和33。龙目岛肺炎球菌携带率中等，耐药分离株比例相对较低。目前的7价肺炎球菌结合疫苗未包含5种最常见血清群和血清型中的至少3种，以及3种最常见不敏感血清群和血清型中的2种。
