晚期不对称性青光眼患者与正常受试者暗适应闪光视网膜电图的b波
The b-wave of the dark adapted flash electroretinogram in patients with advanced asymmetrical glaucoma and normal subjects.
作者信息
Velten I M, Horn F K, Korth M, Velten K
机构信息
Department of Ophthalmology and University Eye Hospital, University of Erlangen-Nürnberg, Schwabachanlage 6, D-91054 Erlangen, Germany.
出版信息
Br J Ophthalmol. 2001 Apr;85(4):403-9. doi: 10.1136/bjo.85.4.403.
AIMS
To evaluate whether the b-wave of the dark adapted flash electroretinogram (ERG) is affected by glaucomatous damage.
METHODS
ERGs were recorded in 35 patients aged 33-65 years with advanced asymmetrical glaucomas (interocular difference of perimetric defects (mean deviation) >2 dB between the two fellow eyes of the glaucoma patients, primary and secondary open angle and low tension glaucomas) and 17 normal subjects matched for age and sex using white flashes of a xenon discharge tube in a Ganzfeld stimulator. After 30 minutes of dark adaptation luminance response functions were obtained using flashes of increasing scotopic luminance (highest 9.4 cd/s/m2, lowest 5.5 log units below it). The parameters Vmax, n, and K of the Naka-Rushton equation were computed from the measurement values based on the usual fitting procedure. These parameters, together with b-wave amplitudes and implicit times for all flash intensities, were compared interocularly and between the normal subjects and those with glaucoma. Correlations were computed between interocular differences of the mean deviation and interocular differences of Vmax, n, K, b-wave amplitudes, and implicit times between the two fellow eyes of the patients with asymmetrical glaucomatous damage.
RESULTS
Implicit times were significantly longer (p<0.005) in the glaucoma patients than in the normal group for flash intensities of 9.4, 5.3, 1.7, 0.53, and 0.17 cd/s/m2. b-Wave amplitudes did not differ significantly between the two study groups. Comparing the two fellow eyes of each patient with glaucoma, Vmax was significantly higher in the less damaged eye than in the more damaged eye. The interocular differences in the mean deviation correlated significantly with the interocular differences in the b-wave amplitudes, implicit times, and Vmax.
CONCLUSIONS
These results suggest that glaucomas can lead to electrophysiologically measurable damage of the inner nuclear layer.
目的
评估暗适应闪光视网膜电图（ERG）的b波是否受青光眼性损害影响。
方法
对35例年龄在33至65岁的晚期不对称青光眼患者（青光眼患者双眼之间视野缺损的眼间差异（平均偏差）>2 dB，包括原发性和继发性开角型青光眼以及低眼压性青光眼）和17名年龄及性别匹配的正常受试者，使用Ganzfeld刺激器中的氙放电管发出的白色闪光记录ERG。在暗适应30分钟后，使用逐渐增加的暗视亮度闪光（最高9.4 cd/s/m²，最低比其低5.5对数单位）获得亮度响应函数。根据常规拟合程序从测量值计算中野-拉什顿方程的参数Vmax、n和K。将这些参数以及所有闪光强度下的b波振幅和隐含时间进行双眼间比较，并在正常受试者和青光眼患者之间进行比较。计算不对称青光眼损害患者双眼之间平均偏差的眼间差异与Vmax、n、K、b波振幅和隐含时间的眼间差异之间的相关性。
结果
对于9.4、5.3、1.7、0.53和0.17 cd/s/m²的闪光强度，青光眼患者的隐含时间明显长于正常组（p<0.005）。两个研究组之间的b波振幅没有显著差异。比较每个青光眼患者的双眼，损伤较轻的眼睛的Vmax明显高于损伤较重的眼睛。平均偏差的眼间差异与b波振幅、隐含时间和Vmax的眼间差异显著相关。
结论
这些结果表明青光眼可导致内核层出现电生理可测量的损害。
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