Curi A L, Muralha A, Muralha L, Pavesio C
Br J Ophthalmol. 2001 Apr;85(4):471-3. doi: 10.1136/bjo.85.4.471.
To describe the authors' experience with discontinuation of anti-cytomegalovirus (CMV) maintenance therapy in patients showing immune recovery following highly active antiretroviral therapy (HAART).
Retrospective analysis of the records of 41 patients who presented with CMV retinitis and whose maintenance therapy was discontinued from March 1997 to December 1999.
41 patients had their anti-CMV therapy discontinued. The mean follow up after discontinuation of maintenance therapy in April 2000 was 20.4 months. At the time of discontinuation of maintenance therapy the lowest CD4+ count was 143 cells x 10(6)/l and only three patients had detectable HIV viral load. No reactivation or progression was seen in any of these patients after suspension of maintenance therapy.
The anti-CMV maintenance therapy could be discontinued safely in patients with CD4+ above 150 cells x 10(6)/l although close follow up remains necessary especially in patients whose CD4+ count drops below this level.
描述作者在高效抗逆转录病毒治疗（HAART）后免疫功能恢复的患者中停用抗巨细胞病毒（CMV）维持治疗的经验。
回顾性分析1997年3月至1999年12月期间出现CMV视网膜炎且停用维持治疗的41例患者的记录。
41例患者停用了抗CMV治疗。2000年4月停用维持治疗后的平均随访时间为20.4个月。在停用维持治疗时，最低CD4 +细胞计数为143个细胞×10（6）/升，只有3例患者可检测到HIV病毒载量。在停用维持治疗后，这些患者中没有观察到任何再激活或进展。
CD4 +高于150个细胞×10（6）/升的患者可以安全地停用抗CMV维持治疗，尽管仍需要密切随访，尤其是CD4 +细胞计数降至该水平以下的患者。
