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Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices.二十二碳六烯酸可改善磷脂酶A(2)抑制剂减弱的大鼠海马切片中的长时程增强效应。
Br J Pharmacol. 2001 Apr;132(7):1417-22. doi: 10.1038/sj.bjp.0703970.
2
A novel role for calcium-independent phospholipase A in alpha-amino-3-hydroxy-5-methylisoxazole-propionate receptor regulation during long-term potentiation.非钙依赖性磷脂酶A在长时程增强过程中对α-氨基-3-羟基-5-甲基异恶唑-4-丙酸受体调节中的新作用。
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3
Neuroprotection of rat hippocampal slices exposed to oxygen-glucose deprivation by enrichment with docosahexaenoic acid and by inhibition of hydrolysis of docosahexaenoic acid-containing phospholipids by calcium independent phospholipase A2.通过富含二十二碳六烯酸以及抑制由钙非依赖性磷脂酶A2介导的含二十二碳六烯酸磷脂的水解对暴露于氧-葡萄糖剥夺的大鼠海马切片进行神经保护。
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4
Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory.抑制大鼠海马体中不依赖钙的磷脂酶A2活性会损害短期和长期记忆的获取。
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5
Long-term potentiation requires activation of calcium-independent phospholipase A2.长时程增强需要非钙依赖性磷脂酶A2的激活。
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6
Impaired corticostriatal LTP and depotentiation following iPLA2 inhibition is restored following acute application of DHA.在急性应用二十二碳六烯酸（DHA）后，iPLA2抑制后受损的皮质纹状体长时程增强（LTP）和去增强作用得以恢复。
Brain Res Bull. 2015 Feb;111:69-75. doi: 10.1016/j.brainresbull.2014.12.010. Epub 2015 Jan 3.
7
Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+.大鼠脑星形胶质细胞中二十二碳六烯酸和花生四烯酸的释放由磷脂酶A2的两种不同同工型介导，且受环磷酸腺苷和钙离子的不同调节。
Br J Pharmacol. 2003 Jul;139(5):1014-22. doi: 10.1038/sj.bjp.0705326.
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[Relationship between hippocampal arachidonic acid content and induction of LTP in aged rats].[老年大鼠海马花生四烯酸含量与长时程增强诱导的关系]
Nihon Shinkei Seishin Yakurigaku Zasshi. 1999 Dec;19(5):273-7.
9
Postsynaptic injection of calcium-independent phospholipase A2 inhibitors selectively increases AMPA receptor-mediated synaptic transmission.突触后注射不依赖钙的磷脂酶A2抑制剂可选择性增加AMPA受体介导的突触传递。
Hippocampus. 2004;14(3):319-25. doi: 10.1002/hipo.10176.
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Interaction between tetanus long-term potentiation and hypoxia-induced potentiation in the rat hippocampus.大鼠海马中破伤风长期增强与缺氧诱导增强之间的相互作用。
J Neurophysiol. 1997 Nov;78(5):2475-82. doi: 10.1152/jn.1997.78.5.2475.

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Metabolism of linolenic acid in developing brain: I. Incorporation of radioactivity from 1-(14)C linolenic acid into brain fatty acids.发育中大脑中亚麻酸的代谢：I. 1-(14)C亚麻酸的放射性掺入大脑脂肪酸中。
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Ca2+-independent phospholipase A2 inhibitor impairs spatial memory of mice.钙离子非依赖性磷脂酶A2抑制剂损害小鼠的空间记忆。
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Arachidonic acid reciprocally alters the availability of transient and sustained dendritic K(+) channels in hippocampal CA1 pyramidal neurons.花生四烯酸相互改变海马CA1锥体神经元中瞬时和持续树突状钾离子通道的可用性。
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Health benefits of docosahexaenoic acid (DHA).二十二碳六烯酸（DHA）对健康的益处。
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Regulation of back-propagating action potentials in hippocampal neurons.海马神经元中反向传播动作电位的调节
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Cancellation of low-frequency stimulation-induced long-term depression by docosahexaenoic acid in the rat hippocampus.
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Nutrition and cognitive function.营养与认知功能。
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Arachidonic acid inhibits transient potassium currents and broadens action potentials during electrographic seizures in hippocampal pyramidal and inhibitory interneurons.花生四烯酸在海马锥体神经元和抑制性中间神经元的脑电图癫痫发作期间抑制瞬时钾电流并延长动作电位。
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二十二碳六烯酸可改善磷脂酶A(2)抑制剂减弱的大鼠海马切片中的长时程增强效应。

Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices.

作者信息

Fujita S, Ikegaya Y, Nishikawa M, Nishiyama N, Matsuki N

机构信息

Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

出版信息

Br J Pharmacol. 2001 Apr;132(7):1417-22. doi: 10.1038/sj.bjp.0703970.

DOI:10.1038/sj.bjp.0703970
PMID:11264234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1572704/
Abstract
  1. We investigated the possible involvement of phospholipase A(2) (PLA(2)) and its products in long-term potentiation (LTP) in the CA1 neurotransmission of rat hippocampal slices. 2. Inhibitors of Ca(2+)-independent PLA(2) (iPLA(2)) prevented the induction of LTP without affecting the maintenance phase of LTP whereas Ca(2+)-dependent PLA(2) inhibitors were virtually ineffective, which suggests a pivotal role of iPLA(2) in the initiation of LTP. 3. We then investigated the effect of docosahexaenoic acid (DHA) and arachidonic acid (AA) on BEL (bromoenol lactone, an iPLA(2)-inhibitor) -impaired LTP, and found that either DHA or AA abolished the effect of BEL. However, DHA did not restore BEL-attenuated LTP when applied after the tetanus. DHA per se affected neither the induction nor maintenance of LTP. Linoleic acid had no effects, either. 4. These results suggest that DHA is crucial for the induction of LTP and that endogenously released DHA during tetanus is sufficient to trigger the formation of LTP.
摘要
  1. 我们研究了磷脂酶A(2)（PLA(2)）及其产物在大鼠海马切片CA1神经传递的长时程增强（LTP）中的可能作用。2. 非钙依赖性磷脂酶A(2)（iPLA(2)）抑制剂可阻止LTP的诱导，但不影响LTP的维持阶段，而钙依赖性磷脂酶A(2)抑制剂实际上无效，这表明iPLA(2)在LTP起始中起关键作用。3. 然后我们研究了二十二碳六烯酸（DHA）和花生四烯酸（AA）对BEL（溴烯醇内酯，一种iPLA(2)抑制剂）损害的LTP的影响，发现DHA或AA均可消除BEL的作用。然而，在强直刺激后应用时，DHA不能恢复BEL减弱的LTP。DHA本身对LTP的诱导和维持均无影响。亚油酸也无作用。4. 这些结果表明，DHA对LTP的诱导至关重要，并且在强直刺激期间内源性释放的DHA足以触发LTP的形成。