Carlsson A, Waters N, Holm-Waters S, Tedroff J, Nilsson M, Carlsson M L
Institute of Physiology and Pharmacology, University of Göteborg, Göteborg, Sweden.
Annu Rev Pharmacol Toxicol. 2001;41:237-60. doi: 10.1146/annurev.pharmtox.41.1.237.
In spite of its proven heuristic value, the dopamine hypothesis of schizophrenia is now yielding to a multifactorial view, in which the other monoamines as well as glutamate and GABA are included, with a focus on neurotransmitter interactions in complex neurocircuits. The primary lesion(s) in schizophrenia does not necessarily involve any of these neurotransmitters directly but could deal with a more general defect, such as a faulty connectivity of developmental origin. Nevertheless, a precise identification of neurotransmitter aberrations in schizophrenia will probably provide clues for a better understanding of the disease and for the development of new treatment and prevention strategies.
尽管精神分裂症的多巴胺假说已被证明具有启发价值，但现在它正让位于一种多因素观点，该观点纳入了其他单胺类物质以及谷氨酸和γ-氨基丁酸，并侧重于复杂神经回路中的神经递质相互作用。精神分裂症的原发性病变不一定直接涉及这些神经递质中的任何一种，而可能与更普遍的缺陷有关，例如发育起源的连接错误。然而，精确识别精神分裂症中的神经递质异常可能会为更好地理解该疾病以及开发新的治疗和预防策略提供线索。
