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母乳喂养婴儿的直肠结肠炎:对幼儿便血鉴别诊断的贡献。

Proctocolitis in breast fed infants: a contribution to differential diagnosis of haematochezia in early childhood.

作者信息

Pumberger W, Pomberger G, Geissler W

机构信息

Division of Paediatric Surgery, University of Vienna, Austria.

出版信息

Postgrad Med J. 2001 Apr;77(906):252-4. doi: 10.1136/pmj.77.906.252.

DOI:10.1136/pmj.77.906.252
PMID:11264489
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1741985/
Abstract

Dietary protein induced proctocolitis in exclusively breast fed infants is rarely taken into consideration as a cause of rectal bleeding or blood streaked stool in the neonatal period and early infancy. Eleven babies are presented in whom it is believed that bleeding through the rectum was due to proctocolitis as a result of allergy triggered by cows' milk protein transferred to the infants via the breast milk. Colonoscopy was performed in five infants, revealing benign eosinophilic proctocolitis. Standard treatment was the exclusion of the allergen from the mother's diet. Resolution of visible rectal bleeding took place within 72 to 96 hours after elimination of the offending protein from the mother's diet.

摘要

在纯母乳喂养的婴儿中,因膳食蛋白质引发的直肠结肠炎,在新生儿期和婴儿早期很少被视为直肠出血或便血的原因。本文报告了11例婴儿,据信其直肠出血是由于通过母乳传递给婴儿的牛奶蛋白引发过敏,导致直肠结肠炎。对5例婴儿进行了结肠镜检查,结果显示为良性嗜酸性直肠结肠炎。标准治疗方法是从母亲饮食中排除过敏原。在从母亲饮食中去除有害蛋白质后的72至96小时内,可见的直肠出血症状得到缓解。

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Proctocolitis in breast fed infants: a contribution to differential diagnosis of haematochezia in early childhood.母乳喂养婴儿的直肠结肠炎:对幼儿便血鉴别诊断的贡献。
Postgrad Med J. 2001 Apr;77(906):252-4. doi: 10.1136/pmj.77.906.252.
2
Eosinophilic colitis in infants.婴儿嗜酸性粒细胞性结肠炎
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3
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Refractory proctocolitis in the exclusively breast-fed infants.纯母乳喂养婴儿的难治性直肠结肠炎
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Pediatrics. 2006 Apr;117(4):e760-8. doi: 10.1542/peds.2005-1069.
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Food protein-induced proctocolitis: Is this allergic disorder a reality or a phantom in neonates?食物蛋白诱导的直肠结肠炎:这种过敏性疾病在新生儿中是真实存在还是虚幻的?
Korean J Pediatr. 2013 Dec;56(12):514-8. doi: 10.3345/kjp.2013.56.12.514. Epub 2013 Dec 20.
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Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes.新生儿孤立性直肠出血与过敏综合征风险。
J Perinatol. 2014 Jan;34(1):39-42. doi: 10.1038/jp.2013.129. Epub 2013 Oct 10.
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Allergic proctocolitis refractory to maternal hypoallergenic diet in exclusively breast-fed infants: a clinical observation.母乳喂养儿的过敏性直肠结肠炎对母亲低敏饮食治疗抵抗:一项临床观察
BMC Gastroenterol. 2011 Jul 16;11:82. doi: 10.1186/1471-230X-11-82.
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Advanced criteria for clinicopathological diagnosis of food protein-induced proctocolitis.食物蛋白诱导的直肠结肠炎临床病理诊断的高级标准。
J Korean Med Sci. 2007 Apr;22(2):213-7. doi: 10.3346/jkms.2007.22.2.213.

本文引用的文献

1
Proctocolitis in exclusively breast-fed infants.纯母乳喂养婴儿的直肠结肠炎
Eur J Pediatr. 1996 Jun;155(6):464-7. doi: 10.1007/BF01955182.
2
Allergic proctocolitis in infants: a prospective clinicopathologic biopsy study.婴儿过敏性直肠结肠炎:一项前瞻性临床病理活检研究。
Hum Pathol. 1993 Jun;24(6):668-74. doi: 10.1016/0046-8177(93)90248-f.
3
Food-induced bleeding from lymphonodular hyperplasia of the colon.食物引发的结肠淋巴小结增生出血
Am J Dis Child. 1993 Aug;147(8):821-3. doi: 10.1001/archpedi.1993.02160320023012.
4
Rectal mucosal major basic protein in infants with dietary protein-induced colitis.饮食蛋白诱导性结肠炎婴儿的直肠黏膜主要碱性蛋白
Ann Allergy. 1993 Jul;71(1):66-9.
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Gastrointestinal bleeding in infancy and childhood.婴幼儿期和儿童期的胃肠道出血。
Gastroenterol Clin North Am. 1994 Mar;23(1):93-122.
6
The polymorph in red is no lady.红细胞中的多形核细胞可不是什么淑女。
J Pediatr Gastroenterol Nutr. 1994 Jul;19(1):4-6. doi: 10.1097/00005176-199407000-00002.
7
Allergic colitis in infancy: clinical and pathologic aspects.婴儿过敏性结肠炎:临床与病理方面
J Pediatr Gastroenterol Nutr. 1994 Jul;19(1):22-6. doi: 10.1097/00005176-199407000-00004.
8
Dietary protein-induced colitis in breast-fed infants.
J Pediatr. 1982 Dec;101(6):906-10. doi: 10.1016/s0022-3476(82)80008-5.
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Rectosigmoidoscopic findings during isolated rectal bleeding in the neonate.
J Pediatr Gastroenterol Nutr. 1987 Mar-Apr;6(2):257-64. doi: 10.1097/00005176-198703000-00017.
10
Hematochezia in infants less than 6 months of age.6个月以下婴儿的便血
Am J Dis Child. 1986 Nov;140(11):1097-8. doi: 10.1001/archpedi.1986.02140250023019.