食物蛋白诱导的直肠结肠炎：一种免疫机制不明的良性疾病。

Food Protein Induced Proctocolitis: A Benign Condition with an Obscure Immunologic Mechanism.

作者信息

Tsabouri Sophia, Nicolaou Nicolaos, Douros Konstantinos, Papadopoulou Athina, Priftis Kostas N

机构信息

Department of Paediatrics, Child Health Department, University of Ioannina School of Medicine, Ioannina, Greece. Stavrou Niarxou Av, Ioannina, 45500, Greece.

University of Manchester, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, United Kingdom.

出版信息

Endocr Metab Immune Disord Drug Targets. 2017;17(1):32-37. doi: 10.2174/1871530316666170331165356.

DOI:10.2174/1871530316666170331165356

PMID:28376708

Abstract

Food protein-induced proctocolitis (FPIP) is the most common colonic manifestation of food allergy in infants, accounting for up to 60% of exclusively breast-fed children. The causative foods derived from the mother's diet, which are then excreted in her milk. The suggested risk factors for the development of FPIP are an immature immune system, altered intestinal permeability and other factors that activate local immune function, such as genetic susceptibility in combination with particularly sensitizing foods. FPIP is an enhanced immune responsiveness of some infants to very small amounts of food antigens, inducing an inflammatory mucosal response, mediated by T cells.

摘要

食物蛋白诱导的直肠结肠炎（FPIP）是婴儿食物过敏最常见的结肠表现，在纯母乳喂养的儿童中占比高达60%。致病食物源于母亲的饮食，随后通过母乳排出。FPIP发生的潜在风险因素包括免疫系统不成熟、肠道通透性改变以及其他激活局部免疫功能的因素，如遗传易感性与特别致敏食物共同作用。FPIP是一些婴儿对极少量食物抗原的免疫反应增强，引发由T细胞介导的炎症性黏膜反应。