Schulten R J, Lobl R T, Ward P
Fertil Steril. 1975 Feb;26(2):131-6. doi: 10.1016/s0015-0282(16)40932-5.
Current research on the mechanism of action of the IUD has focused on a local, low-grade endometritis in preventing blastocystic implantation. With rabbit antisera to rat neutrophils, a neutropenic state was induced in rats having a silk suture in one uterine horn. Assay for nidation sites in the severely polymorphdepleted rats revealed no implantation sites in the IUD horn and an average of 5.8 sites in the control horn, suggesting that inflammation plays a relatively minor role, if any, in the mechanism of action of the IUD.
目前关于宫内节育器作用机制的研究集中在局部轻度子宫内膜炎对防止胚泡着床的作用上。用兔抗大鼠中性粒细胞血清，在一侧子宫角植入丝线的大鼠中诱导出中性粒细胞减少状态。对严重多形核细胞减少的大鼠的着床部位进行检测发现，放置宫内节育器一侧子宫角没有着床部位，而对照侧子宫角平均有5.8个着床部位，这表明炎症在宫内节育器的作用机制中即使有作用，也是相对较小的。
