Bo W J, Krueger W A, Bartley C M
Fertil Steril. 1978 Mar;29(3):351-3. doi: 10.1016/s0015-0282(16)43165-1.
The purpose of this study was to determine whether the luteolytic action of an intrauterine device (IUD) is suppressed following interruption of the continuity between the IUD uterine horn and the adjacent ovary. After several estrous cycles, a silk IUD was placed in the cervical end of one uterine horn of adult hamsters. The animals were then mated, and on day 6 of gestation the ovary and oviduct contralateral to the IUD were removed and a ligature was placed between the IUD horn and the adjacent ovary. The hamsters were killed on day 9 or day 13 of gestation. Fetal development in the contralateral horn was suppressed on day 13 but not on day 9. In the second study the animals were treated as in the first study except that the communication between the IUD horn and the adjacent ovary was severed completely. The hamsters were killed on day 9 or day 13. On both days 9 and 13 normal fetal development was observed in the control horn; no implantation sites were present in the IUD side. In the control (non-IUD) animals of each study, normal fetuses were present in both uterine horns. The study demonstrates that luteolysis does not occur if there is complete disruption of the communication between the IUD horn and ovary. The study also demonstrates that, since implantation did not occur in the IUD horn with a normally functioning ipsilateral ovary, the luteolytic action of the device is not the prime factor in suppressing implantation in the hamster.
本研究的目的是确定宫内节育器（IUD）的黄体溶解作用在IUD所在子宫角与相邻卵巢之间的连续性中断后是否受到抑制。经过几个动情周期后，将丝线IUD放置在成年仓鼠一侧子宫角的宫颈端。然后使动物交配，在妊娠第6天，切除与IUD对侧的卵巢和输卵管，并在IUD所在子宫角与相邻卵巢之间放置结扎线。在妊娠第9天或第13天处死仓鼠。对侧子宫角的胎儿发育在第13天受到抑制，但在第9天未受抑制。在第二项研究中，动物的处理方式与第一项研究相同，只是IUD所在子宫角与相邻卵巢之间的连通性被完全切断。在第9天或第13天处死仓鼠。在第9天和第13天，对照侧子宫角均观察到正常的胎儿发育；IUD侧未出现着床部位。在每项研究的对照（未放置IUD）动物中，两个子宫角均有正常胎儿。该研究表明，如果IUD所在子宫角与卵巢之间的连通性完全中断，则不会发生黄体溶解。该研究还表明，由于在同侧卵巢功能正常的情况下IUD所在子宫角未发生着床，因此该装置的黄体溶解作用不是抑制仓鼠着床的主要因素。
