Gill J M, Mees G P, Frayn K N, Hardman A E
Loughborough University, Loughborough, UK.
Eur J Clin Invest. 2001 Mar;31(3):201-7. doi: 10.1046/j.1365-2362.2001.00799.x.
Moderate intensity exercise reduces postprandial triacylglycerol (TG) concentrations. We tested whether this reflects increased TG clearance. Eight normotriglyceridaemic men, aged 48.3 +/- 7.3 years (mean +/- SD), performed two oral fat tolerance tests (blood samples taken in the fasted state and for six hours after a high-fat meal containing 1.00 g fat, 0.97 g carbohydrate, 58 kJ energy kg-1 fat-free body mass) and two intravenous fat tolerance tests (blood samples in the fasted state and after a bolus injection of Intralipid, 0.1 g fat kg-1 body mass). The afternoon before one oral and one intravenous test, subjects walked briskly for 90 min; no exercise was performed before the control tests. Prior exercise reduced fasting TG concentration similarly in the oral (16 +/- 7 %) (mean +/- SEM) and intravenous (18 +/- 7 %) tests, and reduced postprandial TG concentrations in the oral test by 18 +/- 6 % (all P < 0.05). However, prior exercise did not increase Intralipid clearance (disappearance curve slopes: control, 4.69 +/- 0.49 % min-1; exercise, 4.85 +/- 0.40 % min-1). These data suggest that mechanisms other than increased TG clearance mediate the lower postprandial TG concentrations seen after moderate exercise.
中等强度运动可降低餐后三酰甘油（TG）浓度。我们测试了这是否反映了TG清除率的提高。8名正常甘油三酯血症男性，年龄48.3±7.3岁（均值±标准差），进行了两次口服脂肪耐量试验（在空腹状态下以及摄入含1.00 g脂肪、0.97 g碳水化合物、58 kJ能量/千克去脂体重的高脂餐后6小时采集血样）和两次静脉脂肪耐量试验（空腹状态下以及静脉推注英脱利匹特（0.1 g脂肪/千克体重）后采集血样）。在一次口服试验和一次静脉试验前的下午，受试者轻快步行90分钟；对照试验前不进行运动。运动前，口服试验（16±7%）（均值±标准误）和静脉试验（18±7%）中空腹TG浓度的降低情况相似，口服试验中运动前使餐后TG浓度降低了18±6%（所有P<0.05）。然而，运动前并未提高英脱利匹特的清除率（消失曲线斜率：对照，4.69±0.49%/分钟；运动，4.85±0.40%/分钟）。这些数据表明，除了TG清除率提高外，还有其他机制介导了中等强度运动后餐后TG浓度的降低。
